MESA Personnel and Committees

Key Scientific Personnel

Site Type	Study Site	Key Personnel
Coordinating Center	University of Washington Coordinating Center	Robyn McClelland, PhD (Co-PI) Richard A. Kronmal, PhD (Co-PI) Susan R. Heckbert, MD Bruce M. Psaty, MD Annette L. Fitzpatrick, PhD William T. Longstreth, MD Kayleen Williams, MPH Craig Johnson, MS
Field Centers	Columbia University Field Center	Steven J. C. Shea, MD, MS (PI) Graham R. Barr, MD, Dr. P.H. Benjamin M. Smith, MD, MS, FRCPC Alan D. Guerci, MD Daniel Rabinowitz, PhD Alan R. Tall, MD
	Johns Hopkins University Field Center	Wendy S. Post, MD (PI) Erin D. Michos, MD, MHS Roger S. Blumenthal, MD Pamela Ouyang, MD A. Richey Sharrett, MD, DrPH Moyses Szklo, MD, MPH, Dr.Ph
	Northwestern University Field Center	Norrina B. Allen, PhD(PI) Kiang Liu, PhD (PI) Shah, Sanjiv J.MD Deepak K. Gupta, MD Thomas J. Wang, MD David Green, MD, PhD Philip Greenland, MD
	UCLA Field Center	Karol Watson, MD, PhD (PI) Preethi Srikanthan, MD, MS Alan M. Fogelman, MD Antoinette S. Gomes, MD Sameh Tadros
	University of Minnesota Field Center	Aaron R. Folsom, MD (PI) Lin Yee Chen, MD David R. Jacobs, Jr. PhD Michael Jerosch-Herold, PhD Pamela J. Schreiner, PhD James Pankow, PhD, MPH
	Wake Forest University Field Center	Gregory L. Burke, MD (PI) Alain G. Bertoni, MD Timothy Hughes, PhD Yongmei Liu, PhD Jingzhong Ding, PhD David M. Herrington, MD William G. Hundley, MD
Central Reading/Lab/Analysis Centers	University of Vermont Laboratory	Russell P. Tracy, PhD (PI) Nels C. Olson, PhD Mary Cushman, MD Jon Peter Durda
	Computed Tomography Reading Center UCLA Medical Center Research and Education Institute	Matthew J. Budoff, MD (PI) Robert C. Detrano, MD, PhD Chris Dailing
	MRI Reading Center Johns Hopkins University	João A. Lima, MD (PI) Bruce Wasserman, MD
	Ultrasound Reading Center New England Medical Center	Joseph F. Polak, MD, MPH (PI) Daniel H. O'Leary, MD
	ECG Reading Center Wake Forest University	Elsayed Z. Soliman, MD, MSc (PI)
	LA BioMed/Harbor UCLA	Jerome I. Rotter, MD (PI) Xiuqing Guo, PhD Kent Taylor, PhD
	University of Virginia Genetic Analysis Center	Stephen Rich, PhD (PI) Josyf C. Mychaleckyj, MA, DPhil Michele M. Sale, PhD Ani Manichaikul, PhD
	University of Minnesota Central Lipid Lab	Michael Tsai, PhD (PI) John Eckfeldt, MD, PhD (Co-PI)
Program Office	National Heart, Lung, and Blood Institute	Lorraine Silsbee, MHS Pothur R. Srinivas, PhD, MPH

Committees

The Steering Committee is comprised of

the principal investigators from the Coordinating Center;
six Field Centers;
CT, MRI, and Ultrasound Reading Centers;
Central Laboratory;
and the Project Officer.

Subcommittees include Participant Relations, Design, Laboratory, MRI, CT, Morbidity and Mortality, Operations, Publications, Ancillary Studies, and Quality Control. Subcommittees make recommendations to the Steering Committee, which finalizes decisions.

The charges to the specific committees are as follows:

Steering Committee

Develop and approve all aspects of the study protocol.
Identify modifications of the study protocol or operational policy as necessary, and recommend changes to NHLBI.
Resolve operational problems.
Review reports of the Coordinating Center regarding study progress.
Advise and assist the Field Centers, Coordinating Center, Reading Centers, Central Laboratory and Project Office in the performance of the study.
Review ancillary studies for compatibility with MESA goals, and recommend priorities to the MESA Monitoring Board and NHLBI.

Participant Relations Committee

Oversee the timely provision of individual clinical examination results to participants.
Coordinate and disseminate participant information material.
Facilitate and monitor language translation of all necessary materials into Spanish and Chinese (Mandarin and Cantonese).
Consult with the Operations Committee on maximizing retention.

Design Committee

Evaluate and prioritize proposed examination components and make recommendations to the Steering Committee regarding inclusion.
Consider timing of the components over the course of the study, repetition of the component, participant burden, and cost, along with scientific value.

Operations Committee

Evaluate recommended examination components in terms of participant burden; operationalize approved examination components.
Make recommendations to the Steering Committee regarding methods to minimize participant burden and optimize comfort, interest, and satisfaction.
Assure that participant concerns are addressed and ensure maximum participation.
Develop methods to train examination staff; plan and execute training for examination procedures; develop procedures for exam technicians to obtain and maintain certification to perform study procedures; plan and monitor the pilot study.
Develop the Manual of Operations for clinic operations.
Develop a regular newsletter to keep participants informed about the study and foster good will.
Develop system of "alert" values and procedures for providing feedback to and referrals for participants and their health care providers.
In conjunction with Field Centers, evaluate and recommend modifications to recruitment strategies to assure consistency of procedures among Field Centers, as feasible.
Evaluate status of recruitment, considering balance of relevant ethnic, gender, and age subgroups.
Develop a standard description of recruitment procedures for use in study manuscripts.

Computed Tomography Committee

Develop protocol to measure coronary calcium using electron-beam computed tomography or other computed tomography method.
Develop protocol to read coronary calcium scans.
In conjunction with the Quality Committee, develop and recommend methods to assess comparability among centers and to investigate reasons for lack of comparability or unacceptable variability among Field Centers or within a Field Center.
Recommend further investigation and corrective action, as appropriate.

Ultrasound Committee

Develop protocol to measure carotid intimal-media thickness and plaque using B-mode ultrasound.
Develop protocol to measure flows-mediated vasodilation of the brachial artery, using ultrasound.
Develop protocol to read ultrasound scans.
In conjunction with the Quality Committee, develop and recommend methods to measure Reading Center quality and to assess comparability among centers and to investigate reasons for lack of comparability or unacceptable variability among Field Centers or within a Field Center.
Recommend further investigation and corrective action, as appropriate.

MRI Committee

Identify and recommend to the Steering Committee measures of atherosclerotic plaque in the carotid or aorta, indices of cardiac anatomy and function and other measures appropriate to the technology, within the time constraints of the study, and according to the study goals.
Develop protocols to make measurements and to read MRI scans.
In conjunction with the Quality Committee, develop and recommend methods to assess comparability among centers and to investigate reasons for lack of comparability or unacceptable variability among Field Centers or within a Field Center.
Recommend further investigation and corrective action, as appropriate.

Laboratory Committee

Recommend blood-based laboratory measurements, based on the study goals. Develop a protocol for Field Center phlebotomists.
In conjunction with the Quality Committee, recommend a plan for quality assurance, and develop and recommend methods to assess comparability among centers and to investigate reasons for lack of comparability or unacceptable variability among Field Centers or within a Field Center.
Recommend further investigation and corrective action, as appropriate.

Morbidity and Mortality Committee

Develop protocol for identifying, evaluating, and quantifying, as feasible and appropriate, cardiovascular events, including (1) clinical event manifestations of coronary heart disease, cerebrovascular disease, and congestive heart failure and (2) clinical diagnostic testing and interventions.
Participate in classification of type and severity of cardiovascular events.

Ancillary Studies Committee

For studies intended to be funded from other than contract funds, review, recommend modifications to the science and logistical conduct, and recommend approval or disapproval to the Steering Committee.

Publications and Presentations Committee

Develop, disseminate, and enforce policies for proposing and conducting data analyses; establishing authorship and reinforcing responsibilities of authorship; monitoring progress of data analyses; and use of data in abstracts, presentations, and publications.
Develop and assist in the maintenance of the publications data base of the Coordinating Center.
Recommend to the Steering Committee directions for publications and presentations.
Review, recommend modifications for, and consider for approval all abstracts, presentations, manuscripts, and other data analyses emanating from the study.

Monitoring Board

The MESA Monitoring Board has been appointed by the Director, NHLBI, to advise on the design and conduct of the study and on the analysis and interpretation of results. The Monitoring Board will meet approximately annually.

Helen P. Hazuda, PhD (Chair)
University of Texas Health Sciences Center at San Antonio
Dept. of Medicine, Div. of Clinical Epidemiology

James H. Chesebro, MD
Mayo Clinic
Division of Cardiovascular Diseases

Lewis Wexler, MD
Stanford University
School of Medicine

Kristin Newby, MD
Duke University
Cardiology

Carlos A. Vaz Fragoso, MD
Yale University
Veterans Affairs Medical Center

Kari North, PhD
University of North Carolina at Chapel Hill
Department of Epidemiology and Carolina Center for Genome Sciences

Monika Safford, MD
Weill Cornell Medical College
General Internal Medicine

Phyliss Sholinsky, MSPH
Executive Secretary for Monitoring Board
EBP/DECA/NHLBI/NIH