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LV Mass Calculator


Left ventricular mass (LVM) can be accurately and directly determined using cardiac magnetic resonance (CMR). It is an important predictor of cardiovascular morbidity and mortality1. LVM is known to increase in proportion to overall body size and differs by gender. Thus, to assess an individual’s risk for a cardiovascular event based on LVM, an adjustment for the patient’s body size should be done.

An LV mass "index" is derived by dividing LV mass by factors that include body height and/or weight. The normal range of LV mass index can then be derived from a reference sample of individuals believed to be free of significant risk factors that could otherwise cause LVM enlargement. CMR measured LVM divided by body surface area (BSA) is frequently used clinically to account for body size. However, this adjustment was not derived based on its ability to remove the effect of body size from LVM and the most commonly used formula for computing BSA is based on a study of 9 individuals published in 1916 and its validity and accuracy is unclear.

In MESA2, an adjustment is derived based on an optimal function to predict LVM from height, weight and gender in a healthy subsample. This subsample consisted of MESA participants who were free of diabetes or impaired fasting glucose, hypertension and were of normal weight2. The formula derived from this sample is

     (1) Predicted LVM = 6.82 x (height in meters)0.561 x (weight in kilograms)0.608 for women, and 8.17 x (height in meters)0.561 x (weight in kilograms)0.608 for men.

     (2) The indexed LVM is written as 100xLVM/predicted LVM, so that the scale is in %. This index is called the LVM%predicted.

This index has the nice property that a value of 100 indicates that the indexed LVM is exactly equal to what is predicted by height, weight and gender and values above/below 100 indicates that the LVM is greater/smaller than the predicted LVM. This simple interpretation is an important advantage over other indexed LVM, such as LVM/BSA.

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