Study Overview.

Improving vascular health to delay the onset of Alzheimer’s disease and related dementias is thought to be a critical potential prevention strategy. However, because the links between cardiovascular disease and Alzheimer’s disease pathology remain unclear, there are few specific vascular targets for prevention.

MESA-MIND is focused on understanding how subclinical vascular disease may increase the risk for dementia by creating vascular pathology in brain. This is especially important for racial/ethnic minority groups in the United States who have a higher risk of developing both cardiovascular disease and Alzheimer’s disease.

MESA-MIND will collect detailed cognitive testing and brain imaging from MESA participants and will leverage the detailed vascular phenotypes collected by MESA to determine how subclinical vascular disease may contributes to brain function and the risk for Alzheimer’s disease later in life.

MESA-MIND Visit Components

Visit components may be completed in one day or scheduled over 2 days.

MESA-MIND Visit Components

Blood Pressure: Resting blood pressure will be measured in the right arm after five minutes in the seated position using automated Dinamap.

Anthropometry: Height, weight, waist girth, and hip girth.

Blood Collection: 26 mL of blood are collected.

Arterial Stiffness/Distensibility: Performed using a brachial and leg cuff-based approach with Fukuda VaSera devices.

* Blood pressure, anthropometry, arterial stiffness, and phlebotomy will be measured in fasting state.

Questionnaires: Demographics, socioeconomic and psychosocial status, physical function, medical and family history of dementia, medication use, alcohol intake, and smoking status are collected. Cognitive Function Testing and Study Informant: Cognitive testing includes the National Alzheimer’s Coordinating Center Uniform Data Set version 3 (UDS v3) cognitive battery, in addition to WRAT-5 (Wide Range Achievement Test – 5), AVLT (Auditory-Verbal Learning Test), and QDRS (Quick Dementia Rating System). The participant also identifies a Study Informant who knows them well and can answer questions about their daily life. The Study Informant will complete the QDRS, NPI-Q (Neuropsychiatric Inventory Questionnaire), and FAQ/FAS (Functional Activities Questionnaire). The results of these measures in addition to other data will be used by an adjudication committee to classify cognitive function.

Short Physical Performance Battery (SPPB): The extended version of the SPPB combines the results of gait speed, chair stand and balance tests in order to assess the lower extremity functioning.

Brain MRI: Brain MRI protocol continues to protocol of the MESA Atrial Fibrillation Study (2017-2019) and includes: 3D T1, 3D FLAIR, 3D T2, 3D ASL, DTI 30 dir, BOLD Rest, BOLD Breath Hold, Breath hold compliant, QSM/SWI, and Dixon-T1 Vibe of tongue.

MESA-MIND Cognitive Battery

MESA-MIND Cognitive Battery

Telephone- and Video-administered Cognitive Batteries

MESA-MIND has adapted to continue recruiting during the global COVID-19 pandemic. Since June 2020, MESA-MIND has offered participants the ability to complete a modified version of the cognitive battery in a telephone interview (TCog).

In April 2021, MESA-MIND began offering another alternative, the video cognitive battery (VCog). Tablets equipped with cellular service are shipped directly to participants’ homes. The tablets do not require a WiFi connection or any setup by the participant, they arrive ready to use at the touch of a button.

After completing the TCog or VCog, participants are invited to complete MRI/PET imaging and the in-person Module A components when it is safe to do so according to institutional COVID-19 safety guidelines.

MESA-MIND will continue to offer the TCog and VCog in Visit B to optimize recruitment and participant safety.

MESA-MIND Ancillary Study Timeline

MESA-MIND Timeline

Site Specific Enrollment Targets for MESA-MIND

MESA-MIND Enrollment Targets